How long does HPV vaccine protection last? Current evidence shows protection lasting at least 10-15 years with no signs of waning. Antibody levels remain high, and no booster dose is currently recommended. Based on immune response patterns, protection is likely lifelong. By Web Admin|2026-01-12T16:16:33+00:00January 12, 2026|Does the HPV vaccine prevent|Comments Off on How long does HPV vaccine protection last?